Our Products

Why Enzymes,

  • Enzymes are nature’s workhorses having applications & use in multiple industries. One key area where enzymes are frequently used is in manufacturing of chiral building blocks & chemicals.
  • Enzymes often have high stereoselectivity & regioselectivity, and they work under mild and ambient conditions.
  • They are used to carry out asymmetric reactions, as well as kinetic resolutions for the manufacture of key chiral API intermediates, to do selective deprotection chemistry, resulting in shortening process routes and consequently resulting in substantial cost savings.

Key Advantages of Biocatalysis:

  • High Stereoselectivity & Regioselectivity
  • High selectivity leads to lower impurities.
  • High Throughput
  • Ambient Reaction Conditions leading to Energy Savings
  • Overall Operational Cost Savings
  • Possibility of novel improved, shortened pathways.
  • Lower Environmental Footprint

EnzBiz India Enzyme Portfolio (Current)


A. Biocatalysis Enzymes for chemical intermediates

Transaminase

Sitagliptin transaminase enzyme- transaminase enzyme for conversion of ketoamide to sitagliptin free base.

  • >99% R Selectivity
  • High Conversion & Throughput
  • Ambient Reaction conditions
  • < 24 Hours reaction time

Ketoreductase

Duloxetine KRED enzyme-KRED for producing key chiral intermediate for Duloxetine.

Rosuvastatin KRED enzyme for D2 to D3 which is key intermediate for D5. Quinuclidinone(R3Q) from 3-Quinuclidinone.

  • 99% R Selectivity
  • High Conversion & Throughput
  • Ambient Reaction conditions
  • < 24 Hours reaction time

Ester hydrolases

CALB 10,000LU & 5000LU enzyme for Pregabalin- enzyme for producing key intermediate R-Amide.

  • >99% R Selectivity for CMHA
  • Avoids use of chloriniated solvents
  • Selective enzymatic desymmetrisation of IBGE
  • < 24 Hours reaction time at ambient temperature
  • Immobilised CALB- used for multiple intermediates.


B. Cofactors and recycling enzymes

  • NAD - Nicotinamide adenine dinucleotide
  • NADH - Nicotinamide adenine dinucleotide (oxidized form)
  • NADP- Nicotinamide adenine dinucleotide phosphate
  • PLP - Pyridoxal phosphate


C. Enzyme Screening Kits

Enzyme Kits for screening available, for
  • Transaminases,
  • Ketoreductases,
  • Hydrolases (lipases) &
  • other specialised enzymes


D. Other Enzymes

  • Cellulases
  • Amylases
  • Proteases
  • Lipases
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